Prescribing for children
Children, and particularly neonates, differ from adults in their response to drug. Special care is needed in the neonatal period (first 30 days of life) and doses should always calculate with care. At this age, the risk of toxicity is increased by inefficient renal filtration, relative enzymes deficiencies, differing target organ sensitivity, and inadequate detoxifying systems causing delayed excretion.
Whenever possible, painful intramuscular injections should be avoided in children.
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